Description

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Valium (diazepam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peens). Diazepam affects chemicals in the brain that may be unbalanced in people with anxiety. Valium is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Valium is sometimes used with other medications to treat seizures. Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that typically produces a calming effect. It is commonly used to treat a range of conditions, including anxiety, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, seizures, trouble sleeping, and restless legs syndrome. It may also be used to cause memory loss during certain medical procedures. It can be taken by mouth, inserted into the rectum, injected into the muscle, or injected into a vein. When given into a vein, effects begin in one to five minutes and last up to an hour. By mouth, effects begin after 15 to 60 minutes.

Uses

Diazepam is mainly used to treat anxiety, insomnia, panic attacks and symptoms of acute alcohol withdrawal. It is also used as a premedication for inducing sedation, anxiolysis, or amnesia before certain medical procedures (e.g., endoscopy). Diazepam is the drug of choice for treating benzodiazepine dependence with its long half-life allowing easier dose reduction. Benzodiazepines have relatively low toxicity in overdose.

Diazepam has a number of uses including:

1. Treatment of anxiety, panic attacks, and states of agitation
2. Treatment of neurovegetative symptoms associated with vertigo
3. Treatment of the symptoms of alcohol, opiate, and benzodiazepine withdrawal
4. Short-term treatment of insomnia
5. Treatment of muscle spasms
6. Treatment of tetanus, together with other measures of intensive treatment
7. Adjunctive treatment of spastic muscular paresis (paraplegia/tetraplegia) caused by cerebral or spinal cord conditions such as stroke, multiple sclerosis, or spinal cord injury (long-term treatment is coupled with other rehabilitative measures)
8. Palliative treatment of stiff person syndrome
9. Pre- or postoperative sedation, anxiolysis or amnesia (e.g., before endoscopic or surgical procedures)
10. Treatment of complications with a hallucinogen crisis and stimulant overdoses and psychosis, such as LSD, cocaine, or methamphetamine
11. Preventative treatment of oxygen toxicity during hyperbaric oxygen therapy

Side Effects

Common side effects include sleepiness and trouble with coordination. Serious side effects are rare. They include suicide, decreased breathing, and an increased risk of seizures if used too frequently in those with epilepsy. Occasionally excitement or agitation may occur. Long term use can result in tolerance, dependence, and withdrawal symptoms on dose reduction. Abrupt stopping after long-term use can be potentially dangerous. After stopping, cognitive problems may persist for six months or longer. It is not recommended during pregnancy or breastfeeding. Its mechanism of action is by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA).

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